Does COVID-19 Involve the Retina?

Does a cell protein explain Covid-19 severity

Does a protein on the surface of some of our cells explain why certain people are more at risk from covid-19? The coronavirus attaches to a receptor protein on the surface(ACE) of our cells to gain entry to them. The protein is carried by cells in the nose, lungs and gut. It is possible that variation in how much of this protein people have may help explain why some are more likely to die from ...

Does “Flattening the Curve” Affect Critical Care Services Delivery for COVID-19? A Global Health Perspective

During this coronavirus disease 2019 (COVID-19) global pandemic, nations are taking bold measures to mitigate the spread of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in order to avoid the overwhelming its critical care facilities. While these “flattening the curve” initiatives are showing signs of impeding the potential surge in COVID-19 cases, it is not known whet...

Why does rheumatoid arthritis involve the joints?

A long-standing question in rheumatology is why inflammatory arthritides such as rheumatoid arthritis involve the joints. Many studies have addressed this question; a recent article by Lee et al.1 provides a new answer that is both obvious and intriguing. Rheumatoid arthritis affects the joints because of the essential role of the synovium in regulating inflammation. The normal synovial membran...

Does BCG vaccine induced trained immunity provide cross-protection against COVID-19?

During the global COVID-19 pandemic, the rate of mortality and morbidity was fairly low in Pakistan compared to western countries. Bacille Calmette-Guerin (BCG) vaccination provides cross-protection for a broad range of related and unrelated pathogens. This protection is attributed to the recognition of broadly cross-reactive Pathogen-Associated Molecular Pattern (PAMPS) like molecules. We inve...

COVID-19 in Nursing Homes: The Problematic Management of Residents Without Positive COVID-19 RT-PCR